Background Skin cancer (SC), especially melanoma, is a growing public health burden. Experimental studies have indicated a potential diagnostic role for deep learning (DL) algorithms in identifying SC at varying sensitivities. Previously, it was demonstrated that diagnostics by dermoscopy are improved by applying an additional sonification (data to sound waves conversion) layer on DL algorithms. The aim of the study was to determine the impact of image quality on accuracy of diagnosis by sonification employing a rudimentary skin magnifier with polarized light (SMP). Methods Dermoscopy images acquired by SMP were processed by a first deep learning algorithm and sonified. Audio output was further analyzed by a different secondary DL. Study criteria outcomes of SMP were specificity and sensitivity, which were further processed by a F2-score, i.e. applying a twice extra weight to sensitivity over positive predictive values. Findings Patients ( n = 73) fulfilling inclusion criteria were referred to biopsy. SMP analysis metrics resulted in a receiver operator characteristic curve AUC's of 0.814 (95% CI, 0.798–0.831). SMP achieved a F2-score sensitivity of 91.7%, specificity of 41.8% and positive predictive value of 57.3%. Diagnosing the same set of patients' lesions by an advanced dermoscope resulted in a F2-score sensitivity of 89.5%, specificity of 57.8% and a positive predictive value of 59.9% (P=NS). Interpretation DL processing of dermoscopic images followed by sonification results in an accurate diagnostic output for SMP, implying that the quality of the dermoscope is not the major factor influencing DL diagnosis of skin cancer. Present system might assist all healthcare providers as a feasible computer-assisted detection system. Fund Bostel Technologies. Trial Registration clinicaltrials.gov Identifier: NCT03362138

Background: Early diagnosis of skin cancer lesions by dermoscopy, the gold standard in dermatological imaging, calls for a diagnostic upscale. The aim of the study was to improve the accuracy of dermoscopic skin cancer diagnosis through use of novel deep learning (DL) algorithms. An additional sonification-derived diagnostic layer was added to the visual classification to increase sensitivity. Methods: Two parallel studies were conducted: a laboratory retrospective study (LABS, n = 482 biopsies) and a non-interventional prospective observational study (OBS, n = 63 biopsies). A training data set of biopsy-verified reports, normal and cancerous skin lesions (n = 3954), were used to develop a DL classifier exploring visual features (System A). The outputs of the classifier were sonified, i.e. data conversion into sound (System B). Derived sound files were analyzed by a second machine learning classifier, either as raw audio (LABS, OBS) or following conversion into spectrograms (LABS) and by image analysis and human heuristics (OBS). The OBS criteria outcomes were System A specificity and System B sensitivity as raw sounds, spectrogram areas or heuristics. Findings: LABS employed dermoscopies, half benign half malignant, and compared the accuracy of Systems A and B. System A algorithm resulted in a ROC AUC of 0.976 (95% CI, 0.965-0.987). Secondary machine learning analysis of raw sound, FFT and Spectrogram ROC curves resulted in AUC's of 0.931 (95% CI 0.881-0.981), 0.90 (95% CI 0.838-0.963) and 0.988 (CI 95% 0.973-1.001), respectively. OBS analysis of raw sound dermoscopies by the secondary machine learning resulted in a ROC AUC of 0.819 (95% CI, 0.7956 to 0.8406). OBS image analysis of AUC for spectrograms displayed a ROC AUC of 0.808 (CI 95% 0.6945 To 0.9208). By applying a heuristic analysis of Systems A and B a sensitivity of 86% and specificity of 91% were derived in the clinical study. Interpretation: Adding a second stage of processing, which includes a deep learning algorithm of sonification and heuristic inspection with machine learning, significantly improves diagnostic accuracy. A combined two-stage system is expected to assist clinical decisions and de-escalate the current trend of over-diagnosis of skin cancer lesions as pathological.

In recent years numerous advanced malware, aka advanced persistent threats (APT) are allegedly developed by nation-states. The task of attributing an APT to a specific nation-state is extremely challenging for several reasons. Each nation-state has usually more than a single cyber unit that develops such advanced malware, rendering traditional authorship attribution algorithms useless. Furthermore, those APTs use state-of-theart evasion techniques, making feature extraction challenging. Finally, the dataset of such available APTs is extremely small. In this paper we describe how deep neural networks (DNN) could be successfully employed for nation-state APT attribution. We use sandbox reports (recording the behavior of the APT when run dynamically) as raw input for the neural network, allowing the DNN to learn high level feature abstractions of the APTs itself. Using a test set of 1,000 Chinese and Russian developed APTs, we achieved an accuracy rate of 94.6%. Background and Related WorkThere are numerous topics related to authorship attribution, such as plagiarism detection, books authorship attribution, source code authorship attribution and

Malware allegedly developed by nation-states, also known as advanced persistent threats (APT), are becoming more common. The task of attributing an APT to a specific nation-state or classifying it to the correct APT family is challenging for several reasons. First, each nation-state has more than a single cyber unit that develops such malware, rendering traditional authorship attribution algorithms useless. Furthermore, the dataset of such available APTs is still extremely small. Finally, those APTs use state-of-the-art evasion techniques, making feature extraction challenging. In this paper, we use a deep neural network (DNN) as a classifier for nation-state APT attribution. We record the dynamic behavior of the APT when run in a sandbox and use it as raw input for the neural network, allowing the DNN to learn high level feature abstractions of the APTs itself. We also use the same raw features for APT family classification. Finally, we use the feature abstractions learned by the APT family classifier to solve the attribution problem. Using a test set of 1000 Chinese and Russian developed APTs, we achieved an accuracy rate of 98.6%

As state-of-the-art deep neural networks are deployed at the core of more advanced AI-based products and services, the incentive for copying them (i.e., their intellectual properties) by rival adversaries is expected to increase considerably over time. The best way to extract or steal knowledge from such networks is by querying them using a large dataset of random samples and recording their output, followed by training a student network to mimic these outputs, without making any assumption about the original networks. The most effective way to protect against such a mimicking attack is to provide only the classification result, without confidence values associated with the softmax layer.In this paper, we present a novel method for generating composite images for attacking a mentor neural network using a student model. Our method assumes no information regarding the mentor's training dataset, architecture, or weights. Further assuming no information regarding the mentor's softmax output values, our method successfully mimics the given neural network and steals all of its knowledge. We also demonstrate that our student network (which copies the mentor) is impervious to watermarking protection methods, and thus would not be detected as a stolen model.Our results imply, essentially, that all current neural networks are vulnerable to mimicking attacks, even if they do not divulge anything but the most basic required output, and that the student model which mimics them cannot be easily detected and singled out as a stolen copy using currently available techniques.