Good indoor air quality in the school environment is crucial for health and productivity of the students. Indoor air pollution needs to be taken into consideration, given that one can spend 90% of their time indoor. CO2 and Total VOC is an indoor pollutant that causes pulmonary disorder. This research is to investigate the relationship between exposure of CO2, concentration, total VOC and pulmonary disorder in Junior High School students. This research used cross-sectional design conducted on March - May 2018. The samples were 139 students taken by using simple random sampling. CO2 value was measured by Q-trak, Total VOC was measured by ppbRAE and the lung function value was spirometry. Indoor CO2 concentration in Junior High School of  Depok is 478.70 ppm, the average total concentration VOC is 6.4 x 10-3 ppm, % KVP = 72.66, % VEP1 = 74.52 and % VEP1/KVP = 93.97 in average, and the proportion of students with pulmonary disorder is 3.6%. There is no relationship found between exposure of indoor CO2 concentration and total VOC with lung disorder VEP1/KVP (CO2, p = 1.000 and total VOC p = 0.374) since the number of students with lung disorder is low in number while CO2 concentration and the total VOC level is below the listed threshold. This study found no evidence that exposure was related to pulmonary disorder. A healthy and clean living behavior in school environment needs to be improved and further research on other indoor air pollutant parameters and respiratory disorders or degenerative disease should be conducted with different methods.