-Background -The prevalence of obesity and metabolic syndrome is increasing worldwide and both behavior modification and drug therapy have low adherence. Gastric bypass has shown effective results in both reducing weight and improving comorbidities. Objective -To evaluate the impact of Roux-en-Y Gastric Bypass Surgery (RYGB) on both metabolic syndrome components and the use of associated drugs in obese patients. Methods -Historical cohort of patients subjected to Roux-en-Y Gastric Bypass Surgery (RYGB) between January 2007 and March 2014 in a private clinic. The sample consisted of 273 obese class II and III individuals, 86.4% of whom were female, with age ≥20 years, followed up for 2 months after surgery. Sociodemographic, anthropometric, biochemical, clinical, and drug-use data were collected from patients' medical records. Results -Significant differences were found in weight, body mass index and waist circumference, after 60 postoperative days. Components for metabolic syndrome diagnosis (hypertension P=0.001; hyperglycemia P<0.001; hypertriglyceridemia P=0.006) were reduced after 60 days of postoperative, with the exception HDL-c (P=0.083). There was a significant reduction in the use of antihypertensive (P<0.001), hypoglycemic (P=0.013), lipid lowering (P<0.001), and antiobesity (P=0.010) drugs and increased use of gastroprotective drugs, vitamins, and minerals (P<0.001) after 60 postoperative days. ConclusionPatients subjected to Roux-en-Y Gastric Bypass Surgery exhibited both weight loss and significant improvement not only in metabolic syndrome components (except for HDL-c) but in the use of drugs associated with obesity and metabolic syndrome. HEADINGS -Metabolic syndrome X. Obesity. Gastric bypass. Drug utilization.

Este artigo está licenciado sob forma de uma licença Creative Commons Atribuição 4.0 Internacional, que permite uso irrestrito, distribuição e reprodução em qualquer meio, desde que a publicação original seja corretamente citada. dos pacientes utilizavam medicamentos anti-hipertensivos e 42,9% faziam uso de medicação psiquiátrica. Com relação aos níveis de proteína C reativa, verificou-se uma mediana de 0,81 (0,70-0,97mg/dL). Cento e treze pacientes (57%) referiam ter tido peso excessivo na infância. Má qualidade do sono foi mencionada por 61 (31%) dos indivíduos. Conclusões: A maior parte dos indivíduos com obesidade grau I, II e III e síndrome metabólica, que procurou atendimento na clínica de cirurgia bariátrica, era constituída de mulheres adultas jovens, casadas, com ensino de nível superior ou especializado e com a presença de várias comorbidades somadas ao excesso de peso e caráter inflamatório. Outros achados frequentes incluíram alterações do sono, relato de peso excessivo na infância e uso de mais de um tipo de medicamento. DESCRITORES: obesidade; perfil de saúde; síndrome X metabólica; uso de medicamentos; cirurgia bariátrica. ABSTRACT Aims:To describe the sociodemographic and biochemical profiles, presence of comorbidities, lifestyles, and drug utilization of obese patients with metabolic syndrome eligible for bariatric surgery. Methods: This retrospective cross-sectional study included metabolic syndrome patients with class I, II, and III obesity treated at a specialized clinic in Porto Alegre, Rio Grande do Sul, Brazil, who were candidates for bariatric surgery. The patients were seen between January 2007 and March 2014 and the data for the study were collected from medical records. The following variables were investigated: age, sex, education, marital status, comorbidities, biochemical markers, drug utilization, smoking history, history of childhood overweight, and sleep quality. Patients were classified as class I obesity (BMI=30 to 34.9), class II obesity (BMI=35 to 39.9), and class III, or severe, obesity (BMI≥40). The diagnosis of metabolic syndrome was established according to the International Diabetes Federation. Results: A total of 198 subjects (83.8% of whom were women and 68.7% were married) with a mean age of 40.5±11.1 years (range of 21-69 years) were evaluated. Most of the patients (37.4%) were 30 to 39 years old. With regard to health, 77.3% of the patients had hypertension, 75.8% had dyslipidemia, and 75.3% had gastritis, and it should be noted that 67.2% of the patients were on antihypertensive medications and 42.9% on psychiatric drugs. A median of 0.81 (0.70-0.97mg/dL) was obtained for C-reactive protein levels. One hundred and thirteen patients (57%) reported having had excessive weight in childhood. Poor sleep quality was mentioned by 61 (31%) of individuals. Conclusions: Most individuals with class I, II, and III obesity and metabolic syndrome who sought care at the bariatric surgery clinic were young, adult, and married women with a college degree or higher education present...

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Revisão: Os Autores O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.