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Additional supporting information may be found online in the Supporting Information section at the end of the article. Data S1. Supplementary data. We read with great interest the short report on the validation of the simplified International Prognostic Score 3(IPS-3) for advanced-stage Hodgkin lymphoma (AS-HL) in a population-based British Columbia series. 1 Given that up to onethird of patients with AS-HL will relapse or progress during or after initial treatment, the early and reliable identification of these patients remains crucial. However, this has not been achieved yet, despite the recognition of numerous clinical and biological prognostic factors. 2 The original IPS (IPS-7) [male sex, age ≥45 years, stage IV, haemoglobin <105 g/l,

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Patient: Female, 35-year-old Final Diagnosis: Succesful pregnancy Symptoms: Pain • pregnancy Medication: — Clinical Procedure: — Specialty: Hematology • Obstetrics and Gynecology Objective: Unknown etiology Background: Persistent polyclonal B cell lymphocytosis (PPBL) is a benign clinical condition, which is characterized by persistent absolute polyclonal B lymphocytosis (>4.0 K/μL), with the presence of circulating binucleated lymphocytes on the peripheral blood smear and an extra 3 chromosome long arm i(3q) in most cases. Immunophenotype reveals the polyclonal population of B cell lymphocytes with expression of CD19, CD20, and CD22 antigens, and κ and λ immunoglobulin light chains. Patients are mostly asymptomatic. Although PPBL has a benign clinical course and does not affect the survival expectancy of most patients, pregnancy seems to be extremely rare in these patients, as only 1 case reported so far. Although the real role of immunologic disorders, possibly PPBL, in recurrent pregnancy losses remains unclear, the rarity of successful pregnancy in PPBL patients could be attributed to the possible association of PPBL with infertility or recurrent miscarriages. Case Report: In the present study we present the second published case of a woman with a typical PPBL and recurrent pregnancy loss with a successful pregnancy outcome. Close clinical and laboratory monitoring in combination with the administration of thromboprophylaxis and the induction of mild immunosuppression with low-dose prednisolone may have contributed to the successful outcome of the pregnancy. Conclusions: In conclusion and taking all these findings into consideration, pregnancy in patients with PPBL seems to be extremely rare and the contribution of PPBL to the 2 previous miscarriages in our case could not be excluded.