Groundwater is a useful source of water for various uses in different places. The major challenge in the use of this resource is how to manage and protect it from contamination. The current study was conducted in Morogoro Municipality to identify vulnerable groundwater areas by using DRASTIC-LU/LC model. The study applied eight input parameters, i.e., depth to water table, net recharge, aquifer media, soil media, topography, impact of vadose zone, hydraulic conductivity and land use/land cover patterns, which were overlaid in GIS to generate groundwater vulnerable map. The model used rating (R = 1–10) and weighting (W = 1–5) techniques to assess the effect of each parameter on groundwater contamination. The DRASTIC-LU/LC Vulnerability Index map was classified into low- (area = 29.2 km2), moderate- (area = 120.4 km2) and high-vulnerability zones (area = 124.4 km2). Nitrate analysis was conducted using the cadmium reduction method (DR 890) to assess the validity of the model and it was observed that 55%, 15% and 50% of the samples with unacceptable (>50 mg/L), high (29–50 mg/L) and moderate (14–28 mg/L) nitrate concentrations, respectively, fall into the high-vulnerability zone. Furthermore, 45%, 70% and 50% of the samples with unacceptable, high and moderate nitrate concentrations, respectively, fall into the moderate-vulnerability zone. In the low-vulnerability zone, only 15% of samples were found with a high nitrate concentration.

Commercially available conventional drugs have been used to adulterate herbal products. Considering the rapid growth of herbal products’ market, it is essential to screen herbal products for the presence of conventional drugs. Simple analytical methods are needed for the rapid screening of conventional drugs that are likely to be adulterated in herbal products. Thin layer chromatography (TLC) methods for screening twelve conventional drugs in herbal products have been developed and applied. The analytes were extracted from herbal products using acetonitrile:methanol:acetic acid:water (4:4:1:1, v/v). Solvent mixture of dichloromethane:ethyl acetate:methanol (75:15:10, v/v) separated well trimethoprim, sildenafil, paracetamol, and sulfamethoxazole while pyrimethamine, metronidazole, and sulfadoxine were well separated by dichloromethane:ethyl acetate:methanol (77.5:12.5:10, v/v). In addition, acetyl salicylic acid, ibuprofen, diclofenac, quinine, and lumefantrine were well separated by ethyl acetate:methanol:30% ammonia (75:22.5:2.5, v/v). Chromatographic separations were found to be highly reproducible, and more than 10 samples can be analysed in one run. The method was applied in the screening of 229 herbal products. Consequently, 24.0% of the samples contained one adulterant, while 21.4% contained at least two adulterants. All conventional drugs detected in herbal products were not mentioned on the labels and therefore the consumers are kept unaware of their side effects and health problems. Further studies for confirming and quantitatively determining the adulterants in a wide range of products as well as a systematic toxicological analysis of the adulterants in herbal products are recommended.

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The use of herbal products adulterated with conventional drugs increases the risk of developing microbial resistance and causes herb-to-drug interaction, leading to severe clinical consequences. Herbal products' complex nature has...