Wood-based panel applications recently have expanded and become increasingly competitive, especially within the furniture and civil construction industries. To remain competitive, such products must present physical properties that meet consumer needs. In this context, the incorporation of nanomaterials is gaining momentum, mainly as a means to improve the physical characteristics of panels, thereby expanding their applications. The aim of this study was to evaluate the physical properties of medium density particleboard (MDP) panels after adding various proportions of nanocellulose in place of water to the urea-formaldehyde (UF) adhesive in MDP panel production. The results showed that the addition of nanocellulose resulted in no significant statistical difference in the density and moisture content of the panels. When tested for thickness swelling, only the panel with 100% nanocellulose solution exhibited a significantly higher value. The panels were subjected to scanning electron microscopy (SEM) analysis, which showed that the addition of nanocellulose led to a more polished, less irregular surface. Such physical effects of nanocellulose can potentially make panels more suitable for coating applications. The feasibility of coatings on nanocellulose MDP panels can be verified through future tests to determine the surface roughness of the panels.