This article study aims to explain the use of fishbone waste in its processed form on the daily food product, to analyze to an extent it’s strength and potential in Indonesia and identify its usage. The method used in this study is a qualitative descriptive method using secondary data sources. This research is done by reviewing and analyzing various literature data correlated to fish bone usage. From the associated data, it’s discovered that fish bone mainly used as a calcium source in wich has different value depending on the sources. The utillization of fish bone as food ingredients is mainly used as a substitute or an additive used for product improvements and still being developed to this day.

This study aims to determine the exposure effect of insecticide with the azadirachtin active ingredient on the immunity of nile tilapia. This research was conducted in March and August for the preliminary test and September-October 2022 for the main test at Ciparanje Inland Aquaculture Hatchery, Padjadjaran University. This study used the experimental method of Complete Randomized Design with five treatments and three repeats. The nile tilapia used is 6-7 cm. The treatment used is exposure to insecticide with different doses, namely A (0 ppm), B (26.25 ppm), C (52.5 ppm), D (78.75 ppm), E (105 ppm). Parameters observed included red blood cell count, white blood cell count, feed response, shock response, and macroscopic symptoms up to day 14. Red blood cell and white blood cell data were analyzed in a quantitative descriptive manner. Data on feed response, shock response, and macroscopic symptoms were carried out in a qualitative descriptive manner. Water quality data were analyzed in a quantitative descriptive manner. The results showed that exposure of insecticide with azadirachtin active ingredient interfered fish health by increasing white blood cell count, lowering red blood cell count, disrupting feed response and shock response. The higher the concentration of insecticide given, the more it affects the immunity of tilapia. Treatment without the addition of insecticides is the best treatment in this study.