Giant cell reparative granuloma is a disease with an unknown etiology, characterized of benign locally aggressive lesions invading mandible and maxilla in the head and neck region. These lesions usually present as a mass and cause deformities at bony structures. The use of various medical and surgical procedures in the treatment of the disease with its rare occurrence makes these lesions interesting. In this case report we present a 47 years old female patient who had a painful swelling in the left lower left jaw and oral cavity since 8 months. After her complaints proceeded despite medical therapy, she has been operated and pathology report confirmed a giant cell reparative granuloma. We also discuss differential diagnosis and the achievements in treatment procedures.