As surface-enhanced Raman scattering (SERS) has been used to diagnose several respiratory viruses (e.g., influenza A virus subtypes such as H1N1 and the new coronavirus SARS-CoV-2), SERS is gaining popularity as a method for diagnosing viruses at the point-of-care. Although the prior and quick diagnosis of respiratory viruses is critical in the outbreak of infectious disease, ELISA, PCR, and RT-PCR have been used to detect respiratory viruses for pandemic control that are limited for point-of-care testing. SERS provides quantitative data with high specificity and sensitivity in a real-time, label-free, and multiplex manner recognizing molecular fingerprints. Recently, the design of Raman spectroscopy system was simplified from a complicated design to a small and easily accessible form that enables point-of-care testing. We review the optical design (e.g., laser wavelength/power and detectors) of commercialized and customized handheld Raman instruments. As respiratory viruses have prominent risk on the pandemic, we review the applications of handheld Raman devices for detecting respiratory viruses. By instrumentation and commercialization advancements, the advent of the portable SERS device creates a fast, accurate, practical, and cost-effective analytical method for virus detection, and would continue to attract more attention in point-of-care testing.

The emergence of metamaterials has presented an unprecedented platform to control the fundamental properties of light at the nanoscale. Conventional metamaterials, however, possess passive properties that cannot be modulated post-fabrication, limiting their application spectrum. Recent metasurface research has explored a plethora of active control mechanisms to modulate the optical properties of metasurfaces post-fabrication. A key active control mechanism of optical properties involves the use of mechanical deformation, aided by deformable polymeric substrates. The use of deformable polymeric substrates enables dynamic tuning of the optical properties of metasurfaces including metalenses, metaholograms, resonance, and structural colors, which are collectively relevant for biosensing and bioimaging. Deformable–stretchable metasurfaces further enable conformable and flexible optics for wearable applications. To extend deformable–stretchable metasurfaces to biocompatible metasurfaces, a fundamental and comprehensive primer is required. This review covers the underlying principles that govern the highlighted representative metasurface applications, encompassing stretchable metalenses, stretchable metaholograms, tunable structural colors, and tunable plasmonic resonances, while highlighting potential advancements for sensing, imaging, and wearable biomedical applications.

Optics that are capable of merging with biomaterials create a variety of opportunities for sensing disease, for therapeutics, and for augmenting brain-machine interface. The FDA has approved silk devices for sutures and reconstructive surgery. Recently, a silk product made from regenerated silk protein is FDA approved for orthopedic application, as the understanding of structure and processing technologies of silk fibroin has been improved. Here, we report a facile fabrication process to construct silk microlens array. The process includes preparation of regenerated silk solution and casting on a micropatterned poly(dimethylsiloxane) (PDMS) master. Due to the identical surface area of a unit patterned regime, the silk solution exhibits a partial wetting state in the vicinity of the silk solution–PDMS–vapor interface with same contact angle, and after drying, produces consistent radius of curvature within the microlens array. This in turn provides highly uniform focal length, focal spot diameter, and imaging performance of individual lens. Our results provide the foundation for biophotonic microlens adding new capabilities for implantable and degradable devices from regenerated silk protein.