This report is the first to describe a case of canine metatarsal fistulation in a Shikoku dog. A male Japanese Shikoku (9 years old; weight, 18 kg) presented with an ulcer and hemorrhagic discharge from a fistula on the metatarsal region of the left hind leg. X‐ray examination showed a normal foot structure and the absence of shadows that might suggest the presence of a foreign body in the metatarsal region of the left hind leg. Histological examination of a biopsy of the lesion revealed granulation tissue; with mild infiltration by lymphocytes, plasma cells, and histiocytes, but no apparent infectious microorganisms. Oral administration of prednisolone with cyclosporin was effective in treating this disease, which might have been immune mediated.