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An intravenous glucose tolerance test was carried out in i i patients with chronic manganese poisoning. Prolonged reactionary hypoglycaemia was observed. The underlying mechanism is discussed. It may be due to a disturbance of the hypothalamo-pituitary-adrenal axis.In seven of these patients total serum proteins were estimated and were separated electrophoretically. The albumin: globulin ratios were lower in patients than in controls. There were significant reductions in serum albumin concentrations and increases in concentrations of cxl and ,B globulins.Since the early discovery of chronic manganese poisoning among workers manufacturing chlorine gas in France using manganese ore (Couper, I837), many other reports from Europe, North Africa,

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Study ObjectivePaclitaxel‐induced peripheral neuropathy is a significant clinical problem can markedly deteriorate patient's quality of life (QoL). Preclinical evidence exists about the preventive capacity of cilostazol against peripheral neuropathy. However, this hypothesis has not yet been clinically investigated. This proof‐of‐concept study evaluated the effect of cilostazol on the incidence of paclitaxel‐induced peripheral neuropathy in patients with non‐metastatic breast cancer.DesignThis is a parallel randomized placebo‐controlled trial.SettingThe Oncology Center at Mansoura University, Egypt.PatientsPatients with breast cancer scheduled to receive paclitaxel 175 mg/m2 biweekly.InterventionsPatients were randomized to either cilostazol group who received cilostazol tablets 100 mg BID, or to control group who received placebo instead.MeasurementsThe primary endpoint was the incidence of paclitaxel‐induced neuropathy evaluated through common terminology criteria for adverse event (NCI‐CTCAE) version 4. Secondary endpoints included assessment of the patient's QoL by the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group‐Neurotoxicity (FACT‐GOG‐NTx) subscale. Exploratory outcome measures included changes in serum levels of biomarkers namely nerve growth factor (NGF), and neurofilament light chain (NfL).Main ResultsThe incidence of grade 2 and 3 peripheral neuropathies were significantly lower in the cilostazol group (40%) compared to the control group (86.7%) (p < 0.001). The incidence of clinically significant worsening in neuropathy‐related QoL was higher in control group compared to the cilostazol group (p = 0.001). A higher percent increase from baseline in serum NGF was observed in the cilostazol group (p = 0.043). The circulating levels of NfL deemed comparable between the two arms at the end of the study (p = 0.593).ConclusionAdjunctive use of cilostazol is as a novel option that might reduce the incidence of paclitaxel‐induced peripheral neuropathy and improve the patients' QoL. Future larger clinical trials are warranted to confirm these findings.