A 54-year-old male farmer was seen in May 1990 with a violaceous, exulcerated tumor, 2x1.5 cm in diameter, localized to the sternal area of the chest. The tumor had been present for 30 years, showing slow progressive growth; it was excised, but recurred 2 years before our initial evaluation. The tumor was again excised with a wide free margin. The histopathologic study showed an ill-defined, epithelial neoformation, formed by lobules of clear polygonal cells at the deep dermis and subcutaneous tissue; there was a second group of smaller cells with a basaloid aspect, a few of them presenting slight atypia. The tumoral lobules were surrounded by a myxoid material with vascular proliferation. The epidermis was normal. The histopathologic report was of a malignant nodular hidradenoma. No evidence of lymph node or distant metastases was found. One year after the excision, the tumor recurred at the surgical site, and an axillary lymph node showed metastatic cells. The lesion was excised for a third time and the patient was lost to follow-up.

No abstract

Our cases do not seem to correspond to any of the three entities which are manifested clinically by acral keratotic plaques. All of these women washed clothes by hand on a stone washboard for many hours every day. As there is no clinical or histologic evidence of actinic damage, chronic trauma seems to be the cause of the dermatosis in this type of patient. We propose the term "occupational lenticular acral keratosis" for our cases.

In 1960, when he was 5 years old. Patient 1 was first noted to have plane wart‐like lesions on the dorsum of his hands and on the back of his neck. He was seen at age 14 when he presented with pityriasis versicolor‐like lesions on his trunk and persistent warts on his hands and neck. A biopsy confirmed the clinical diagnosis of epidermodysplasia verruciformis (EV); however, he was lost to follow‐up until age 30 when he presented with hundreds of plane wart‐like lesions on his face, neck, and hands, as well as reddish scaly plaques on his trunk, arms, and forearms. One of the plaques on his right forearm was confirmed to be Bowen's disease on biopsy. He received treatment with etretinate 1 mg/kg per day for 8 months. He did not develop any new lesions while on the drug; however, he was lost to follow‐up again for another 8 years until he was 38 (Fig. 1), when he presented with an invasive squamous cell carcinoma (SCC) on the dorsum of his right hand. Patient 1 is the eldest of six siblings (two men, and four women). His brother, who is 5 years younger, is Patient 2. No other members of the family are affected so far. Our patients are a product of a consanguineous marriage of first cousins. Patient 2 was first documented with symptoms of his disease at approximately age 6. He was seen on one occasion when he was 9 years old with pityriasis versicolor‐like lesions on his trunk. He was not seen again until age 25, when he presented with several verrucous tumors on his right upper and lower and left lower eyelids, dorsum of nose, and right retroauricular zone; he also had hundreds of reddish, scaly, pityriasis versicolor‐like lesions on his trunk, arms, and forearms and warts on his wrists and dorsum of his hands. Biopsies showed invasive SCCs of his nose, right eyelids, and retroauricular zone, as well as Bowen's disease of the lower left eyelid and suprasternal area. He was treated surgically and alo given etretinate 1 mg/kg per day for 8 months during which no new lesions were detected. At age 27, he had a recurrence of nasal SCC. He was treated surgically and with methotrexate but, as tumor progression was noted and not having anything better to offer our patient, it was then decided to treat him with radiotherapy. One year later he presented with a second recurrence of SCC and since then has never been without midfacial aggresive tumor activity; he was treated again, first surgically and then using chemotherapy with methotrexate and 5‐fiuorouracil. Two years later, at age 32, he developed a third recurrence of his midfacial SCC affecting his glabellar zone, left malar area, and upper lip. The first two tumors responded well to surgery; the third one (upper lip) recurred so he received radiotherapy once again. He then received interferon alpha 2b 5 million units, three times a week for 12 months; during this time he developed SCO in his right ear, upper lip (both treated surgically and with radiotherapy), neck, and wrist (treated surgically). He is now 35 years old. In order to identify human papillomaviruses (HPV...