Chemical investigatio n of the Indonesian sponge Lissodendoryx (Acanthodoryx) fibrosa yielded the new 2‐aminoimidazole alkaloids lissodendrins A (1) and B (2). Their structures were unambiguously determined by extensive NMR spectroscopic (1H, 13C, ROESY and long‐range HMBC) studies and mass spectrometric (HRESIMS/MS) data. Lissodendrins A (1) and B (2) possess unprecedented skeletons with the latter compound bearing a (p‐hydroxyphenyl)glyoxal moiety, which is rarely encountered in natural products. A plausible biosynthetic pathway for these new metabolites is proposed.

Lissodendrins A (I) and B (II): 2-Aminoimidazole Alkaloids from the Marine Sponge Lissodendoryx (Acanthodoryx) fibrosa. -(MOKHLESI, A.; HARTMANN, R.; ACHTEN, E.; CHAIDIR, E.; HARTMANN, T.; LIN, W.; DALETOS*, G.; PROKSCH, P.; Eur. J. Org. Chem. 2016, 4, 639-643, http://dx.