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To evaluate the usefulness of phenotypic and genotypic analyses for the epidemiologic typing of methicillinresistant Staphylococcus aureus (MRSA), we characterized 64 epidemic MRSA isolates and 10 sporadic methicillin-susceptible S. aureus isolates from a university hospital and 18 MRSA isolates from hospitals in different geographical areas. Chromosomal DNA macrorestriction analysis with Sstll was resolved by pulsed-field gel electrophoresis and compared with antibiotype analysis, phage type analysis, and standard genomic DNA restriction analysis with BgM. Indices of the discriminatory ability of these methods were 0.982,

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