ObjectiveThis study assessed impaired fasting glucose and associated factors among perinatally HIV-infected adolescents and youths in Dar es salaam Tanzania.BackgroundImpaired fasting glucose is a marker of heightened risk for developing type 2 diabetes among perinatally HIV-infected individuals. Therefore, identifying individuals at this stage is crucial to enable early intervention. Therefore, we assessed impaired fasting glucose (IFG) and associated factors among perinatally HIV-infected population in Dar es salaam Tanzania. MethodsA cross-sectional study was conducted among 152 adolescents and youth attending HIV clinic at Muhimbili National Hospital and Infectious Disease Centre from July to August 2020. Fasting blood glucose (>8 hours) was measured using one-touch selects LifeScan, CA, USA. We also examined C-Reactive Protein and interleukin-6 inflammatory biomarkers in relation to impaired fasting glucose (IFG). Associations between categorical variables were explored using Chi-square, and poison regression with robust variance was used to calculate the prevalence ratios.ResultsOf the 152 participants, the majority were male (n=83[54.6%]), and the median age was 15(14-18) years. Overweight or obesity was prevalent in 16.4%, while more than one in ten (13.2%) had high blood pressure (≥149/90mmHg). All participants were on antiretroviral therapy (ART); 46% had used medication for over ten years, and about one in three had poor medication adherence. Among the recruited participants, 29% had impaired fasting glucose. The odds of IFG were two times higher in males compared to females (PR, 2.07, 95% CI 1.19 -3.59 p=0.001). Moreover, we found with every increase of Interleukin 6 biomarker there was a 1.01 probability increase of impaired fasting glucose (PR, 1.01, 95% CI 1.00 – 1.02 p=0.003).ConclusionAbout one in three perinatally HIV-infected youths had impaired fasting glucose in Dar es Salaam, Tanzania, with males bearing the biggest brunt. Moreover, with every increase of 1.101 of the probability of having IFG increased. This calls for urgent measures to interrupt the progression to diabetes disease and prevent the dual burden of disease for this uniquely challenged population.

Aims: Mumps infection and its complication remain under recognized public health problem in Tanzania, as there are no national screening program and sero-epidemiological surveys. This makes it difficult to devise control interventions including administration of vaccinations. We therefore determined the Sero-prevalence of Mumps among Unvaccinated Children Attending Regional Referral Hospitals in Dar es salaam, Tanzania. Study Design:  A hospital based cross-sectional study. Place and Duration of Study: Outpatient departments of three regional hospitals in Dar es Salaam Tanzania: Amana, Mwananyamala, and Temeke hospitals, from March to June 2021. Methodology: Three hundred and sixty children aged 1 - 16 years were included in the study. A structured questionnaire was used to collect participants' information. Serum samples were tested for mumps immunoglobulin G antibodies using an enzyme linked immune-sorbent assay. Proportions were used to describe children's social demographic and clinical characteristics, and binary logistic regression was used to estimate the odds of exposure to mumps virus. A p-value < 0.05 was considered statistically significant. Results: The mean age was 7.6 ± 4.1, half of them were females. More than three quarters (77%) of the children had Mumps Immunoglobulin-G. Mumps sero-prevalence among under-fives was 58.8%, among 5-8 years was 80%, 9-12 years was 86% and for 13-16 year was 88%. Compared to under-fives, children in the ages of 5-8, 9-12 and 13-16 had four times. (OR 4.19 95% CI 1.49-11.7), five times (OR 5.84 95% CI 1.89-18.12) and six times (OR 6.00 95% CI 1.63-21.43) higher odd of mumps exposure respectively. The number of siblings in the house, going to school, and previous history of parotid gland enlargement were not associated with mumps sero-positivity. Conclusion: The mumps virus is circulating in a high proportion among children in Dar es Salaam and the likelihood of exposure increases with age.