Purpose There is growing interest in the concept of ‘deaths of despair’ (DoD)—defined as deaths from three causes: suicide, drug poisoning, and alcohol-related conditions—as a more comprehensive indicator of the impact of psychological distress on mortality. The purpose of this study is to investigate the degree of commonality in trends and geographic patterning of deaths from these causes in England and Wales. Methods WHO mortality data were used to calculate age-standardised, sex-specific temporal trends in DoD mortality and in mortality from suicide, drug poisonings, and alcohol-related conditions in England and Wales, 2001–2016. Three-year average crude rates were calculated for English local authorities for 2016–2018 and associations between rates were assessed using Spearman’s rank correlation. Results Between 2001 and 2016, the DoD mortality rate increased by 21·6% (males) and 16·9% (females). The increase was largely due to a rise in drug poisoning deaths, with limited tracking between trends in mortality by each cause. DoD mortality risk was highest in middle-aged people; there were rises in all age groups except 15–24 year old males and 65 + females. There were strong positive correlations (r = 0.66(males) and 0.60(females)) between local authority-area drug poisoning and alcohol-specific mortality rates in 2016–2018. Correlations of these outcomes with suicide were weaker (r = 0.29–0.54). Conclusions DoD mortality is increasing in England and Wales but there is limited evidence of commonality in the epidemiology of cause-specific mortality from the component causes of DoD (suicide, drug poisoning and alcohol-related conditions), indicating the need for tailored prevention for each outcome.

Persons experiencing homelessness or rough sleeping are a vulnerable population, likely to be disproportionately affected by the COVID-19 pandemic. The impact of COVID-19 infection on this population is yet to be fully described in England. We present a novel method to identify COVID-19 cases in this population and describe its findings.A phenotype was developed and validated to identify persons experiencing homelessness or rough sleeping in a national surveillance system. Confirmed COVID-19 cases in England from March 2020 to March 2022 were address-matched to known homelessness accommodations and shelters. Further cases were identified using address-based indicators, such as NHS pseudo postcodes.In total, 1835 cases were identified by the phenotype. Most were <39 years of age (66.8%), and male (62.8%).The proportion of cases was highest in London (29.8%). The proportion of cases of a minority ethnic background and deaths were disproportionality greater in this population, compared to all COVID-19 cases in England.This methodology provides an approach to track the impact of COVID-19 on a subset of this population and will be relevant to policy making. Future surveillance systems and studies may benefit from this approach to further investigate the impact of COVID-19 and other diseases on select populations.

ObjectiveTo examine inequalities in preconception health between migrant women in potentially vulnerable situations and non-migrant women.DesignNational cross-sectional study.SettingData from the National Health Service (NHS) Maternity Services Data Set (MSDS) version 1.5, using data submitted by NHS maternity services in England.ParticipantsAll 652,880 women with an antenatal booking appointment between 1/4/2018 and 31/3/2019 were included. Data regarding migration status were available for 66.2% of the study population (n=432,022).Outcome measuresPrevalence of preconception indicators were compared between probable migrants (those with complex social factors and English not their first language), possible migrants due to English not being a first language (without complex social factors), possible migrants due to complex social factors (who speak English as a first language) and unlikely migrants (those who speak English as a first language without complex social factors). Complex social factors include recent migrants, asylum seekers or refugees, difficulty reading or speaking English; alcohol and/or drugs misuse; all those aged under 20; and/or experiencing domestic abuse. Odds ratios were calculated comparing preconception indicators among those identified as migrants compared to unlikely migrants.ResultsWomen identified as probable migrants (n=25,070) had over twice the odds of not taking folic acid before pregnancy and of having their first antenatal booking appointment after the recommended 10 weeks gestation compared to unlikely migrants (n=303,737), after adjusting for area-based deprivation level, mothers age at booking, number of previous live births and ethnicity (odds ratio 2.15 (95% confidence interval 2.06 to 2.25) and 2.25 (2.18 to 2.32) respectively). Probable migrants had increased odds of previous obstetric complications and being underweight at booking, but lower odds of recorded physical and mental health conditions (apart from diabetes and hepatitis b), smoking and obesity in unadjusted and adjusted analyses.ConclusionsInequalities between migrant women in potentially vulnerable situations and non-migrants exist across many preconception indicators. Findings highlight the opportunity to improve preconception health in this population in order to reduce health inequalities and improve perinatal and neonatal outcomes.