A burgeoning number of studies are demonstrating aluminium in human brain tissue. While research has both quantified and imaged aluminium in human brain tissue in neurodegenerative and neurodevelopmental disease there are few similar data for brain tissue from non-neurologically impaired donors. We have used microwave assisted acid digestion and transversely heated graphite furnace atomic absorption spectrometry to measure aluminium in twenty brains from donors without recognisable neurodegenerative disease. The aluminium content of 191 tissue samples was invariably low with over 80% of tissues having an aluminium content below 1.0 μg/g dry weight of tissue. the data for these control tissues were compared with data (measured using identical procedures) for sporadic Alzheimer's disease, familial Alzheimer's disease, autism spectrum disorder and multiple sclerosis. Detailed statistical analyses showed that aluminium was significantly increased in each of these disease groups compared to control tissues. We have confirmed previous conclusions that the aluminium content of brain tissue in Alzheimer's disease, autism spectrum disorder and multiple sclerosis is significantly elevated. Further research is required to understand the role played by high levels of aluminium in the aetiology of human neurodegenerative and neurodevelopmental disease.
Citizens’ exit polls are performed by local voters to verify the official reported election results. Five citizens’ exit polls were run in southeast Kansas during the Nov 8th 2016 election. These exit polls were designed specifically to verify computer generated vote counts and run solely by volunteer labor, all local citizens who were willing to put in the necessary hours on Election Day to conduct the poll and later, to count the results by hand. These exit polls were able to obtain high participation rates resulting in the ability to detect small yet statistically significant differences. All five polling stations surveyed show evidence of multiple statistical anomalies in both the pattern and size of the errors between the official results and exit poll results although biases were not uniformly oriented across sites. The small discrepancies found in the studied races were insufficient to alter the outcomes. Non-response bias and unintentional errors were evaluated as potential causes; those explanations were plausible in some but not all cases. These results show a pattern of discrepancies between the exit polls and computer counted results displaying consistent bias within sites. This would be an expected outcome of a deliberate manipulation of the computer results. While this data doesn’t conclusively prove election interference and manipulation of votes counts, it should be taken seriously as a sign of such interference. Doubts about the accuracy of the reported results are appropriate unless other plausible explanations for the discrepancies can be found.
The approaches used to compute engineering design values (A-basis and B-basis) and acceptance sampling criteria were developed independently in the twentieth century. This was a practical approach for that time period but it isn't working well for new materials with process dependent strength and modulus characteristics, such as carbon fiber composite materials. This paper lays out an approach designed to meet industry needs for identification of engineering design values applicable to the majority of manufacturing facilities using approved processing procedures for carbon-fiber composite materials along with corresponding acceptance criteria set to specific values for both the consumer's and the producer's risks.
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