HighlightsSuperficially porous silica particles enable high resolution separation of nucleic acids.The pore size of the C18 superficially porous silica particles significantly effects resolution.Optimum separations of small oligonucleotides obtained with 80 Å pore sizes.Optimum resolution of oligonucleotides (>19 mers) was observed with pore sizes of 150 Å.Improved resolution of larger dsDNA/RNA molecules was achieved with pore sizes of 400 Å

No abstract

No abstract