Settleable particulate matter (SPM) is an atmospheric pollutant harmful to human health and the environment in high concentrations. Despite this fact, no up-to-date information on SPM levels exists for the capital of Chile, Santiago (7 million inhabitants). To address this knowledge gap, SPM sedimentation rates, including soluble and insoluble components, were measured at three different urban sites from July to November of 2016. We compare the measurements with ambient and meteorological information, as well as urban typology settings. Our results indicate SPM deposition rates between 2.5 and 3.9 g/(m 2 ⋅30 days). Only one site exceeded the national limit of 4.5 g/(m 2 ⋅30 days), but we found an increasing trend in all three sites. SPM and its insoluble sedimentation rates increased during warm and dry months and presented significant correlations with meteorological parameters. The highest sedimentation rates were measured at the location with the least permeable surfaces and the lowest green spaces, while the lowest sedimentation rates were found in the sites with abundant green spaces and permeable soil. No significant differences were detected in the soluble components. Our results suggest that SPM levels in Santiago are close to the national limit and may increase with climate change and urban expansion.