An effective integrative review can provide important insight into the current state of research on a topic and can recommend future research directions. This article discusses different types of reviews and outlines an approach to writing an integrative review. It includes guidance regarding challenges encountered when composing integrative reviews, such as fair representation of different perspectives and synthesizing that knowledge to yield new insights. An integrative review is of unique value among other types of knowledge-synthesis vehicles, such as narrative or systematic reviews and meta-analyses. Because each has distinctive but important approaches to synthesizing empirical knowledge, our protocol for writing integrative reviews is designed to complement these other knowledge-synthesis vehicles to best advance organization science.

Virulence factor production in Staphylococcus aureus is largely under the control of the accessory gene regulator (agr) quorum sensing system. There are four agr groups, all of which exhibit bacterial interference: each agr type synthesizes a cyclic autoinducing peptide (AIP) with a distinct sequence that activates its cognate AgrC receptor and inhibits activation of others. To better understand inhibitory AIP-AgrC interactions, we aimed to identify the minimal molecular determinants required to inhibit both non-cognate and cognate receptors. This minimization of the AIP pharmacophore also may have therapeutic relevance as the use of native AIPs to block virulence of non-cognate agr strains can prevent the establishment of an infection in vivo. We synthesized and evaluated the inhibitory activities of 10 AIP derivatives based on a truncated AIP analogue that inhibits all four agr types. To carry out the rapid, parallel synthesis of these peptides, we employed a new linker for Fmoc-based thioester peptide synthesis. Our results identify key structural elements that are necessary for AgrC inhibition and reveal key differences between non-cognate and cognate inhibitory requirements.

We present evidence that numerically accurate quantum calculations employing modern internucleon forces do not reproduce the proton analyzing power, A(y), for p- 3He elastic scattering at low energies. These calculations underpredict new measured analyzing powers by approximately 30% at E(c.m.) = 1.20 MeV and by 40% at E(c.m.) = 1.69 MeV, an effect analogous to a well-known problem in p-d and n-d scattering. The calculations are performed using the complex Kohn variational principle and the (correlated) hyperspherical harmonics technique with full treatment of the Coulomb force. The inclusion of the three-nucleon interaction does not improve the agreement with the experimental data.