Background:The mechanism of repression of inflammasome caused by Francisella tularensis is not known. Results: F. tularensis represses AIM2 and NLRP3 inflammasomes in a FTL_0325-dependent fashion.
Conclusion: Repression of inflammasome by F. tularensis results in fulminate infection.Significance: This study advances the understanding of mechanisms of immune suppression caused by F. tularensis.
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