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The inconclusive results were most probably influenced by a very low grass pollen season. Other factors such as the extent of the pre-seasonal treatment could potentially have contributed. The tolerability profile was acceptable for further development.

Fast updosed immunologically enhanced SCIT with an optimized allergen/adjuvant ratio induced significant immunological effects and had an acceptable safety profile. Clinical efficacy will be investigated in future clinical trials.

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Inhaltsverzeichnis 1 Einleitung und Definitionen ¼ 273 2 Psychosomatische Diagnostik ¼ 273 2.1 Welche Möglichkeiten haben wir als HNO-¾rzte, um eine psychosomatische Diagnose zu stellen und eine entsprechende Therapie einzuleiten? ¼ 273 2.2 Fragebögen ¼ 274