Background Sensitive skin is a common concern with 60%–70% of women and 50%–60% of men reporting skin sensitivity and redness. Facial redness is associated with a higher incidence of embarrassment, social anxiety, and diminished quality of life. While there is no cure for sensitive skin, it can be controlled. Aims The objective of this 12‐week, open‐label clinical trial was to assess the efficacy and tolerability of a topical facial regimen for treating subjects with facial redness and sensitive skin. Patients/Methods Enrolled subjects were healthy male and female individuals, 25–60 years old with Fitzpatrick skin types I–VI who were seeking treatment for moderate or severe facial redness. Subjects were provided with products which were applied each morning and evening. The investigator assessed change in subject appearance using Overall Redness and Global Improvement Scales and subjects rated changes in appearance and tolerability with self‐assessment scales. Results The mean Overall Redness Scale Score improved by 34% and 25% at Weeks 8 and 12, respectively. There was Mild or Moderate improvement in Global Improvement Scale scores beginning at Week 2 with over 50% achieving Marked improvement by Week 12. All subjects Agreed or Strongly Agreed that their facial redness was less noticeable, their skin appeared less inflamed, overall skin appearance improved, and skin looked and felt healthier at Week 12. The regimen was well‐tolerated. Conclusions This study demonstrated a treatment regimen designed to neutralize skin redness and calm inflamed skin was well‐tolerated and improved the symptoms of sensitive skin.

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