Signaling molecules such as Cdc42 and mitogen-activated protein kinases (MAPKs) can function in multiple pathways in the same cell. Here, we propose one mechanism by which such factors may be directed to function in a particular pathway such that a specific response is elicited. Using genomic approaches, we identify a new component of the Cdc42-and MAPK-dependent signaling pathway that regulates filamentous growth (FG) in yeast. This factor, called Msb2, is a FG-pathway-specific factor that promotes differential activation of the MAPK for the FG pathway, Kss1. Msb2 is localized to polarized sites on the cell surface and interacts with Cdc42 and with the osmosensor for the high osmolarity glycerol response (HOG) pathway, Sho1. Msb2 is glycosylated and is a member of the mucin family, proteins that in mammalian cells promote disease resistance and contribute to metastasis in cancer cells. Remarkably, loss of the mucin domain of Msb2 causes hyperactivity of the FG pathway, demonstrating an inhibitory role for mucin domains in MAPK pathway activation. Taken together, our data suggest that Msb2 is a signaling mucin that interacts with general components, such as Cdc42 and Sho1, to promote their function in the FG pathway.[Keywords: Morphogenesis; cell polarity; signal transduction; pseudohyphal growth; specificity] Supplemental material is available at http://www.genesdev.org.

Abstract:Heritage sites are constantly changing due to natural processes, and this change can happen fastest at the coast. Much legislation has been enacted to protect sites of historic interest, but these do not protect sites from natural processes. Change is already happening, and climate change predictions suggest that the pace will accelerate in the future. Instead of seeing the potential destruction of heritage sites as a disaster, we should embrace the opportunity that they can provide for us to learn about the past and to plan for the future. Heritage laws often enshrine a policy of preservation in situ, meaning that our most spectacular sites are preserved in a state of equilibrium, with a default position of no permitted intervention. However, the options for threatened coastal sites mirror those of shoreline management plans, which usually recommend either the construction of a coastal defence or, more likely, a strategy of managed retreat, where erosion is allowed to take its course after appropriate mitigations strategies have been enacted. Managed retreat can lead to a range of research projects, some of which would not normally be possible at similar, unthreatened and legally protected monuments. Such research also has the potential to involve members of the public, who can help in the discovery process, and cascade what they have learned through their communities. Information shared can be about the heritage site itself, including how communities in the past coped at times of climatic stress; and also about the processes that are now threatening the monument, thus helping teach about present day climate change.

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A project by SCAPE, NAS, and local volunteers at Newshot Island on the Clyde near Glasgow has documented an important ships graveyard dating to the early 20th century. The vessels tell the story of the creation of the Clyde Navigation, represent a significant aspect of the river's history, and exemplify the technological and industrial development of the region. The survey and research revealed that the remains on site include the earliest diving support vessel known to have been recorded, and has resulted in the designation of the remains as a Scheduled Ancient Monument by Historic Environment Scotland.

Author post-print (accepted) deposited by Coventry University's Repository