As infecções causadas por Cryptococus spp. são oportunistas, urbanas e associadas a imunossupressão. A mortalidade é estimada em 10% nos países desenvolvidos e 43% nos emergentes. O Objetivo foi avaliar os aspectos clínico-epidemiológicos da criptococose na região do oeste paulista. Trata-se de estudo transversal, baseado nas informações dos prontuários de pacientes em um hospital do interior de São Paulo, de 2006 a 2018. Aplicou-se análise descritiva por meio da frequência absoluta (n) e relativa (%); e estatística através dos testes x2 e Exato de Fisher. Também foi calculado Risco Relativo (RR) e Odds Ratio (OD) para óbito. A neurocriptococose foi a principal manifestação clínica em 64,50%. A pesquisa direta no líquor foi positiva em 85,71% das amostras, o imunodiagnóstico em 93,80% e a cultura, padrão-ouro para fungo, em 55,55% dos casos. O teste x2 e o Exato de Fisher não demonstraram diferença entre sexo, faixa etária, forma clínica ou óbito. RR e OD foram considerados baixos. A associação dos aspectos epidemiológicos da criptococose com seus sinais clínicos permite o diagnóstico precoce da doença, diminuindo o desenvolvimento de quadros graves. Além disso, as terapias antirretrovirais de alto desempenho diminuíram drasticamente a ocorrência de óbitos em pacientes com HIV.

The high resistance to antimicrobials has made hospitals a potentially dangerous environment for the development of HAIs, especially when associated with multi-resistant bacteria such as A. baumannii. The work aimed to evaluate the incidence of multidrug-resistant Acinetobacter baumannii described in the literature through a meta-analysis. A meta-analysis of a qualitative and quantitative nature was carried out in which original articles and review articles that presented data on the occurrence and existence of multidrug resistance in Acinetobacter baumannii were evaluated. The Scientific Electronic Library on Line (SciELO) and Medical Literature Analysis and Retrieval System Online (Pubmed / MEDLINE) databases were consulted using the descriptors "Acinetobacter baumannii," "multi-resistance," "IRAS," "incidence." Most studies were carried out in 2018. In general, most studies were cross-sectional 85.00% (n = 17) and cohort 15.00% (n = 3). In the selected studies, 5877 cases were reported, of which 3544 corresponded to multi-resistant species of Acinetobacter. The cumulative prevalence ratio corresponded to 0.603 with a 95% confidence interval [0.590 to 0.615]. The analysis of the temporal trend of the Ratio of the prevalence of multidrug-resistant Acinetobacter baumanni according to the year of the selected studies indicated that the PR suffered a decline in 2009 and 2013 and a new tendency to increase from 2015 and suffered small fluctuations until 2019, the trend did not show significant (R2 = 0.0772). Therefore, the MDR profile is worrying, given the currently available therapeutic alternatives.

COVID-19 is an emerging infectious disease that represents a significant threat to public health worldwide. That indicates the need for adherence to public policies with preventive, control, and rapid and accurate diagnosis measures as part of the measures to contain the pandemic's advance. This study aimed to analyze the main laboratory findings of the respiratory syndrome caused by the new coronavirus SARS-CoV-2 through a narrative review of the literature. The coronavirus viral RNA detection technique has been described as the principal methodology used for clinical diagnosis. Among the laboratory findings, lymphocytopenia decreased hemoglobin and serum albumin values, increased lactate dehydrogenase (LDH) and C-Reactive Protein (CRP), increased erythrocyte sedimentation rate (ESR) were observed. D- dimer has been linked to poor prognosis in critically ill patients. In the current context, laboratory tests can contribute to the early identification of signs of severity and poor prognosis of the respiratory syndrome caused by the new SARS-CoV-2.

SARS-CoV-2 belongs to the family of coronaviruses and is an infectious disease that threatens public health worldwide. The definitive diagnosis of the new coronavirus is made by molecular tests used in breathing tests, such as, for example, or rubbing the throat. However, most of the time, infectious diseases are diagnosed employing symptoms, laboratory, and image exams, like x-ray, computed tomography, and nuclear magnetic resonance imaging. The present study aimed to analyze the main imaging tests found in the respiratory syndrome caused by the new coronavirus. This research deals with a narrative review of the literature published so far, having a descriptive and qualitative nature. A search took place in the databases of virtual health libraries. It was refined by Latin American and Caribbean Literature in Health Sciences (LILACS), Electronic Scientific Library (SCIELO), BIREME (Regional Library of Medicine), and MEDLINE. Among the authors published, the occurrence of ground-glass opacities, isolation, or multifocal, consolidations such as cardiomegaly, decreased air space, aerobocograms, and pleural effusion were observed. Also, some findings had atypical characteristics. We conclude that in several formed patterns found to characterize a lung disease, with main optional bilateral, peripheral, and essential features, with rounded morphologies, presence of lymph node enlargement, pleural effusion, excavation, and nodules in the most severe cases. In this way, it is suggested that the imaging exams be complementary to the laboratory diagnosis.