MIC>400, area under the curve: MIC ratio higher than 400 up to 600 (Vancomycin PK/PD target); 100% f∆T>MIC, time dose interval that free drug serum levels is higher than MIC (Meropenem PK/ PD target); CSLI, clinical standard laboratory institute, database USA; GSA, global sepsis alliance; ICU, intensive care unit; LAIS,
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