age 59 years (range 41-83); 62.5% men). The median number of bags per patient was 13.5 (range 3-66). Conclusion and relevance The CPRP in the pharmacy service increases the safety of administration, allows preparation under aseptic conditions and enables the optimisation of available stock. As it contains more volume, it facilitates the work and protects the nursing staff by reducing the frequency of contact with the patient.

30.7% (n=46) received antipsychotic monotherapy, and 70.7% (n=106) a combination of more than one AP (c 2 =12.9; p<0.01).Number of prescriptions with doses of APs within the technical sheet (£100%) was 62 (41.3%), and outside (>100%) was 89 (59.3%), of which even 29 (19.3%) prescriptions presented doses of APs !200%. Of the APS >100%, 95.3% corresponded to the sum of different APs and only 4.7% to a single APs.Percentage of patients who have exceeded 100% of the dose is significantly higher among those who have been prescribed >1 APs (c 2 =39.4; p<0.05).Percentage mean APs dose per patient: 127.7% (range 28-379). Conclusion and relevance More than half (59.3%) of the APs prescriptions exceed the sum of 100% doses; of these, >90% are due to the sum of the percentage doses of the different APs. Although it may reflect the complexity and resistance of the pathologies treated, it does not agree with the recommendations of the national and international guidelines regarding the management of APs.Current electronic prescription systems do not alert when the maximum dose is exceeded due to the sum of the combination of APs, which opens a possible way of improvement.