Objective: The aim of this work was to find out if serum level of vascular endothelial growth factor shows changes with the onset of preeclampsia that could be used as predictor for preeclampsia. Patients and Methods: This study included 60 primigravidae women divided into three groups, group (I) included 20 normal women, group (II) included 20 women with mild preeclampsia and group (III) included 20 women with severe preeclampsia.VEGF was measured in all groups and compared Results: VEGF concentrations measured in severe preeclampsia group were significantly higher than mild preeclampsia group and control group. Thus, VEGF concentrations could be used as a predictor for diagnosis and follow up of severity of preeclampsia. VEGF had significant value for discrimination between patients with PE (mild and severe) and controls with cutoff value >632.4 ng/l which had a sensitivity of (82.5%) and specificity of (85%). Also, serum VEGF concentration for discrimination between patients with severe PE and those with mild or no PE was >1335.5 ng/l with specificity of (92.5%) and sensitivity of (90%). VEGF had significant value for prediction of adverse fetal outcomes with cutoff value >741.5 ng/l which had a sensitivity of (95.65%) and specificity of (72.97%). Conclusion: According to the previous data obtained, serum VEGF level can be used as a predictor for preeclampsia.