Background: Insulin exerts metabolic and growth-stimulating actions both through its own receptors and the receptors of its homologous factors (IGFs), although with different degrees of affinity. The A receptor of insulin acts more intensely on the cell membrane, with a metabolic response, whereas the B receptor is quickly internalized, stimulates cell growth, can be directed to the treatment of wounds difficult to heal. The intraregional use of insulin ensures its absorption, greater stability, longer activity period and absence of contact with necrotic or enzymatic materials capable of preventing or changes its activity in topical use. Objective: in this article, we aimed to study the role of insulin in dermatology and skin diseases. Methods: We searched online databases (PubMed, Embase, and the Cochrane Library), to include studies that discuss the role of insulin in skin diseases, all types of studies are included. Conclusion: Insulin therapy has been shown to be effective and without adverse effects. Different intervals between applications did not change the obtained results. The availability of insulin and the safety of its use indicate the authors' method as an advantageous therapeutic option in the recovery of tissues. The availability, low cost and wide knowledge available on this substance justify its indication as a therapeutic method for, are difficult to heal wounds.