This study analyses informal settlements and the regional highway network in the Greater Cairo Region of Egypt to propose alternatives to reduce regional spatial fragmentation that may lead to spatial segregation. Findings indicate that the street structure of informal settlements provides a configuration that supports social interaction for their residents. While the regional highway network can act to physically disconnect the wider region by isolating or splitting neighbourhoods, some highways can act as an integrator. Analysis at the urban scale can identify points in the settlements' street networks where they can be connected to the regional transport network, which could have an impact on regional consolidation.
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