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Objectives The aim of this study is evaluating the effect of using various prepartion of dentin matrices on bone regeneration in New Zeland white rabbit model. Design The study was conducted on fifty adult New Zealand rabbits, 20 for preparation of experimental materials and 30 for surgical procedures. They were randomly assigned into three equal groups as follow one control group: no treatment and two experimental groups including demineralized group: treated with demineralized dentin matrix (DDM) only; and mixed group: treated with a hybrid of (50% DDM + 50% undemineralized dentin matrix). A rounded critical size defect (10 mm in diameter, 5 mm in depth) was created in the body of mandible. After 3- and 6-weeks postsurgery, the bone regeneration was evaluated by light microscope and computed tomography analysis. Results Histological and computed tomography analysis revealed that both dentin matrices had largely resorbed and induced new bone formation at both experimental groups compared to the control group, with statistically higher percentage of new bone formation and bone mineral density in the mixed group. Conclusion We concluded that although both dentin matrices improve bone regeneration but, hybrid dentin matrix yielded better results compared to DDM group.