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Summary Rabbit lymph node cells incubated in vitro with antigenic material for transfer to recipient rabbits were subjected to roentgen irradiation, and the effects of such irradiation were studied by observation of the production of antibody in the recipient animals. Following transfer of cells irradiated at doses between 150 r and 400 r there was a reduction in the subsequent agglutinin titers of the recipients ranging from substantial reduction to complete suppression. Such effects were found whether the cells were irradiated in the tissues of the donor or recipient animal or in vitro. The transfer of irradiated cells to normal recipients did not yield higher titers than did transfer of these cells to irradiated animals. The possibility was examined that lymph node cells engaged in antibody formation might have greater resistance to irradiation injury than “resting” cells, as measured by their effectiveness in the formation of antibodies to another antigen. The data of some experiments suggested such an effect, but this was not consistently demonstrated throughout the study.