7 3D printing can be applied for point-of-care personalised treatment. This study aimed to determine 8 the manufacturability and characteristics of 3D printed, drug-loaded implants for alcohol misuse. 9Disulfiram was the drug substance used and polylactic acid (PLA) the base material. Implantable 10 devices were designed in silico. Drug and PLA were placed into the extruder to produce a 5% blend at 11 1.75mm diameter. Material characterisation included differential scanning calorimetry (DSC), 12 thermogravimetric analysis (TGA) plus inverse gas chromatography (iGC-SEA). Implantable constructs 13 from the PLA feedstock were acquired. The extrusion processes had a detrimental effect on the API-14 base blend. DSC and TGA analysis indicated drug-base interactions. Thermal history was found to 15 influence iGC probe interaction. Drug-base incompatibilities must be considered during 3D printing. 16 17