ImportanceRacially and ethnically minoritized individuals remain underrepresented in graduate medical education relative to their proportion in the population. While many programs and initiatives have been developed to address this problem, there is little consensus regarding strategies that work to improve representation across specialties.ObjectiveTo examine and synthesize evidence-based practices that have been used to increase the proportions of underrepresented in medicine (URiM) trainees at US residency and fellowship programs.Evidence ReviewThe authors searched PubMed, Google Scholar, Embase, PsycInfo, ERIC, Cochrane Reviews, Cochrane Trials, CINAHL, Scopus, and PROSPERO electronic databases to identify relevant studies published through January 2022. They screened all titles and abstracts for relevance and read full-text articles to identify articles reporting reliable data describing the outcomes of interventions to improve racial and ethnic diversity among trainees.FindingsTwenty-seven articles were included in this review. Two studies reported on fellowship programs. The most common interventions included holistic review (48%), decreased emphasis on United States Medical Licensing Examination Step 1 scores (48%), and explicit institutional messaging regarding the importance of diversity (37%). A combination of interventions was associated with an increased number of URiM applicants, interviewees, and matriculants across various medical and surgical specialties.Conclusions and RelevanceIn this scoping review, approaches and interventions associated with increased diversity in residency and fellowship programs were identified. Continued efforts are necessary to sustain such efforts and assess long-term outcomes.
Two new D‐A type polymers PBDSe‐DPP and PBDSe‐ID were synthesized to explore new ideal semiconducting polymers, by conjugating acceptor unit diketopyrrolopyrrole/isoindigo to a donor unit benzo[1,2‐b:4,5‐b′]diselenophene, which is designed by substituting the sulfur atom with a selenium atom in the benzo[1,2‐b:4,5‐b′]dithiophene. The thermal, optical, electrochemical, photoelectric and photovoltaic properties of the two polymers were studied systematically. Relatively high open circuit voltage (0.7 and 0.75 V) and fill factor (>65%) were demonstrated for both polymers. Huge increase (by 64% and 120%) of the short circuit current density was achieved for both polymer based devices by using additive compared to the corresponding reference without additive, resulting in decent power conversion efficiency of 3.7% and 2.5% respectively with only simple optimizing consideration. We believe this class of BDSe polymer possesses a good potential to be alternatives of active material for photovoltaic applications.
The consumption of alcohol has long been associated with the development of liver disease as well as cancers including colorectal cancer (CRC). Leading healthcare concerns include the prevalent use of alcohol and the high burden of CRC mortality. Many CRC deaths are attributed to the development of colorectal liver metastasis (CRLM) as the liver is the foremost site of CRC spread. However, an association has not been defined for the role of alcohol intake and related liver injury with the development of CRLM. Here, a mapping review of recent research was undertaken to evaluate the relationship between alcohol consumption and the risk of CRLM. The literature search revealed 14 articles meeting the inclusion criteria that included patient database analyses and preclinical studies. Most of the human data analyses found alcohol use independently associates with worse CRC outcomes. The preclinical evaluations identified several pathways involved in the alcohol-mediated promotion of CRLM burden and CRC cell metastatic behavior. The limited number of studies identified exposes a significant need for more prospective analyses to define the role of alcohol intake and advanced CRC as well as the translation of preclinical research to fully characterize targetable mechanisms for the generation of new therapeutic options.
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