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The present article examines how job demands and resources are related to indices of strain among healthcare professionals during virus pandemics. The article also presents the results of a study examining the relationships between COVID‐19 demands (e.g., lack of personal protective equipment, concerns about infecting family members), resources (meaningful work, social support), and mental health strain within a sample of emergency medicine personnel over six consecutive weeks. COVID‐related demands and hours worked were hypothesized to be positively related to mental health strain, whereas meaningful work and social support were hypothesized to be negatively related to mental health strain. Hours worked the prior week were hypothesized to exacerbate the positive relationships between COVID‐19 demands and mental health strain, whereas the resources of meaningful work and social support were expected to buffer the relationships. Multilevel models controlling for mental health strain the prior week revealed that COVID‐19 demands, along with hours worked, were each related to higher mental health strain during the week. Hours worked magnified the within‐person relationship between personal COVID‐19 demands and mental health strain. Contrary to hypotheses, social support and meaningful work were not related to mental health strain. Discussion focuses the implications of the findings for healthcare professionals.

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