To gain insight into the role of prostanoids in human kidney function, we examined the distribution of cyclooxygenase (COX) 1 and COX-2 by immunofluorescence and immunohistochemistry in human kidneys from adults of various age groups. COX-1 was detected in the collecting ducts, thin loops of Henle and portions of the renal vasculature. COX-2 was detected in the renal vasculature, medullary interstitial cells, and the macula densa. In addition, COX-2 immunoreactivity was noted in afferent arteries and the macula densa of the renal cortex and was more evident in the kidneys of older adults.z 1999 Federation of European Biochemical Societies.

No abstract

every note and every vowel within the sphere of the vocal 'lips' begins, i.e., the perfect note. (The system is being taught here in Glasgow on the coordinate movement principle, and is most successful in its results.) That phrase at the end of Mr. Freer's letter-re chest resonance-is a nasty knock for the nasal resonance clique. Mr. Hilton's belated echo from Africa-' like the flowers that bloom in the spring,'-has little to do with the case. ' Fair play's a jewel,' and I do not think it just of anyone because he obviously does not understand, or is afflicted with mental strabismus, to regard one's statements as 'doubtful.' I have quoted scientific facts, and, as Burns says, 'Facts are chiels that winna' ding.' I shall not presume on your space to quote any youthful prodigy. The experiment of filling the nasal cavities with milk was performed by the late A. B. Bach, of Edinburg, who has related the result in one of his able books on the voice.-Yours, &c.,