Highlights The sensitivity of evaluated SARS-CoV-2 immunoassays ranged from 95.6% to 97.8%. The specificity was 92.1% for Euroimmun IgG and ≥ 98.9% for Abbott IgG, Wantai Ab and DiaPro confirmation IgG assays. A lack of specificity was observed for low positive Euroimmun IgG results (ratio<5) and inconclusive RT-PCR results. A lack of sensitivity was observed for early serology (<14 days) or late RT-PCR testing (>30 days).