Targeting the activation function-1 (AF-1) domain located in the N-terminus of the androgen receptor (AR) is an attractive therapeutic alternative to the current approaches to inhibit AR action in prostate cancer (PCa). Here we show that the AR AF-1 is bound by the cochaperone Bag-1L. Mutations in the AR interaction domain or loss of Bag-1L abrogate AR signaling and reduce PCa growth. Clinically, Bag-1L protein levels increase with progression to castration-resistant PCa (CRPC) and high levels of Bag-1L in primary PCa associate with a reduced clinical benefit from abiraterone when these tumors progress. Intriguingly, residues in Bag-1L important for its interaction with the AR AF-1 are within a potentially druggable pocket, implicating Bag-1L as a potential therapeutic target in PCa.

Background One of the most common medical problems associated with pregnancy is hypertension. Hypertensive disorders of pregnancy (HDP), which has been attributable to abnormal placentation may have adverse effects on both mother and foetus if left unchecked. The objective of this study was to determine the prevalence of this condition and its effect on placental morphology as well as maternal and perinatal outcomes. Materials and methods This was a prospective case-control study, conducted at Komfo Anokye Teaching Hospital (KATH), Ghana between February 2018 and July 2018. The progression of pregnancy in normotensive and hypertensive pregnant women, and the eventual perinatal outcomes were closely followed. Statistical analysis was performed using IMB-SPSS version 23. Associations were considered significant at p values of ≤ 0.05. Results From a total of 214 deliveries recorded during the period of study, 84 (39.25%) were hypertensives. Forty four (52%) of the hypertensives had preeclampsia, 28 (33.3%) had gestational hypertension, 6 (7.1%) had eclampsia, 4 (4.8%) had chronic hypertension, and 2 (2.4%) had preeclampsia superimposed on chronic hypertension. The frequency of placental haematoma, placental infarction, and placental calcification in the normotensives were significantly (p = 0.001) lower than that of the hypertensives. The mean placental weight (p = 0.01), placental volume (p = 0.001), placental diameter (p = 0.03), and placental thickness (p = 0.001) of the normotensives were significantly higher than those of the hypertensives. The number of normotensives in whom labour was induced, who had their babies delivered by caesarean section, and who were admitted after they had given birth were significantly (p = 0.001) lower than that of hypertensives who underwent similar procedures. No stillbirths were recorded in the normotensives compared with four in the hypertensives. The number of babies delivered to the normotensives who were admitted to the NICU was significantly (p = 0.001) lower than those delivered by hypertensives. Conclusion There was a high prevalence of hypertensive disorders of pregnancy in the study site. Pregnant women who developed HDP are at a risk of developing placental abnormalities that adversely affected perinatal outcomes. These adverse effects can be curtailed by embarking on a vigorous health education drive.

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27 Background: One of the most common medical problems associated with pregnancy is 28 hypertension. Hypertensive disorders of pregnancy (HDP), which has been attributable to 29 abnormal placentation may have adverse effects on both mother and foetus if left 30 unchecked. The objective of this study was to determine the prevalence of Hypertensive 31 Disorders of Pregnancy (HDP), the morphological variations of human placenta in HDP, 32 and maternal and perinatal outcomes in HDP.33 Materials and Methods: This was a prospective case-control study, conducted at Komfo 34 Anokye Teaching Hospital (KATH), Ghana. The progression of pregnancy in normotensive and 35 hypertensive pregnant women, and the eventual perinatal outcomes were closely followed.36 Statistical analysis was performed using IMB-SPSS version 23. Associations were considered 37 significant at p values of  0.05.38 Results: From a total of 214 deliveries recorded during the period of study, 84 (39.25%) 39 were hypertensives. Forty four (52%) of the hypertensives had preeclampsia, 28 (33.3%) 40 had gestational hypertension, 6 (7.1%) had eclampsia, 4 (4.8%) had chronic hypertension, 41 and 2 (2.4%) had preeclampsia superimposed on chronic hypertension. The frequency of 42 placental haematoma, placental infarction, and placental calcification in the 43 normotensives were significantly (p=0.001) lower than that of the hypertensives. The 44 mean placental weight (p = 0.01), placental volume (p = 0.001), placental diameter (p = 45 0.03), and placental thickness (p = 0.001) of the normotensives were significantly higher 46 than those of the hypertensives. The number of normotensives in whom labour was 47 induced, who had their babies delivered by caesarean section, and who were admitted 48 after they had given birth were significantly (p=0.001) lower than that of hypertensives 49 who underwent similar procedures. No stillbirths were recorded in the normotensives 50 compared with four in the hypertensives. The number of babies delivered to the 3 51 normotensives who were admitted to the NICU was significantly (p=0.001) lower than 52 those delivered by hypertensives. 53 Conclusion: There was a high prevalence of hypertensive disorders of pregnancy in the 54 study site. The condition adversely affected placental development and perinatal 55 outcomes. These adverse effects can be curtailed by embarking on a vigorous health 56 education drive. 57 58 Key Words: Hypertensive Disorders of Pregnancy; Maternal outcome; Placento-Foetal outcomes 4 59 Introduction 60 Physiological changes occur in almost every pregnancy to aid in the nourishment and survival 61 of the foetus. Biochemical parameters are good indicators of these adaptive changes in most 62 organ systems and have shown to be different from the non-pregnant state [1]. These changes 63 become very significant during complications of pregnancy. Hypertension is one of the medical 64 problems that mostly affect pregnant women and it remains an important cause of both maternal 65 and foetal morbidity/mortality. Stud...