This chapter will talk about diabetes in African children living in Africa. It will cover diabetes, the classification in general, and the gray areas of diabetes in Africa. It will also cover part of the genetics of diabetes around Africa and its shortfall. The chapter will also look at the management of diabetes in an African setting, where insulin is stored in pots, and the challenges that a child with diabetes goes through in Africa. This chapter will be useful for pediatric endocrinologists, pediatricians, adult diabetologists, doctors, nurses, and everyone in the health sector dealing with children with diabetes.