Badjo et al., J. Appl. Biosci. 2017 Effets d'une consommation prolongée de «koutoukou» (boisson alcoolique artisanale) sur la mémoire spatiale chez la souris. 11557Journal of Applied Biosciences 116: 11557-11565 ISSN 1997-5902 Effets d'une consommation prolongée de «koutoukou» (boisson alcoolique artisanale) sur la mémoire spatiale chez la souris. ABSTRACT Objective: The aim of this study was to determine the effects of "koutoukou", a traditional drink after the fermented sap of distilling oil palm (Elaeis guineensis) on memory skills Methodology and Results: 62 Swiss mice of which 22 controls and 40 experimental animals were subjected to a T-labyrinth test. The controls consumed ordinary water as a drink. The experimental animals were divided into two groups: 20 koutoukou alcoholic mice for 3 months and 20 other koutoukou alcoholic mice for 6 months. Comparison of the serial spontaneous alternation between the two experimental groups showed a more marked decrease in this rate (alternation) in the alcoholic animals during 6 months. As for the delayed alternation of tests, they showed that this rate drops significantly at 6 am (the time between the acquisition phase and the return phase) in mice treated koutoukou for 6 months against 24 hours in those alcohol for 3 month. Conclusion and application of results: Chronic koutoukou consumption leads to deficits in both working memory and episodic memory.

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