Diabetes mellitus is a chronic disease that is complex and can be suffered for entire life. Patients with this disease are often desperate with a long therapy program, so that patient compliance can affect the success of the treatment. Factors that influence the treatment adherence can be analyzed using the PRECEDE model. To study the behavioral factors that affect patient adherence to oral antidiabetic drug consumption through the PRECEDE model. This study is an analysis and cross sectional research. Data retrieval is done by non random sampling with accidental sampling technique. The number of respondents obtained in this study were 58 patients who met the inclusion criteria. The research instrument used in this study was a questionnaire to be proposed using the Spearman test. The results of the Spearman correlation test showed that the coefficient correlation values for patient knowledge, patient attitudes, health facilities, and health worker behavior were 0.069 (p-value: 0.604), 0.226(p-value: 0.087), 0.171 (p-value: 0.199), and 0.287 (p-value: 0.029). The behavior of health workers has an influence on patient adherence to taking oral antidiabetic drugs.