HighlightsObtaining a detailed medical history is important, and we should not depend on examination tools when dealing with patients.Unexplained findings should raise suspicions regarding other possible diagnoses, and the same non-conclusive procedures should not be repeated.Following this advice can prevent unnecessary operative procedures and the complication of perforation of the uterus.

Problem statement:To compare the effects of both abdominal and laparoscopic diathermy (PCOS) on the ovulatory process. Design: Prospective study. Setting: Tikrit Teaching Hospital, Iraq. Approach: A total of 40 infertile patients, these patients were divided into two groups, each group of 20 patients. The first group was undergoing abdominal diathermy; while the second group undergoing laparoscopic diathermy. The ovulatory response were assessed by both LH and testosterone levels. Results: After Diathermy, there were significant effects on regularity of menses: 25% in first group had regular cycle and in second group 60% had regular cycle. Decrease in LH and testosterone Level after surgery were significantly different in both groups: 35% in first group and 70% in second group. Conclusion: Laparoscopic diathermy showed higher rates of regular resumption of menses and decrease in LH and testosterone level than abdominal diathermy.

Background: Preterm labor is a major obstetrics problem because it associated with high morbidity and mortality to the born baby. Many studies were done to study different aspects of its risk factors, diagnosis and treatment to decrease its incidence, bad sequel to the fetus and recurrence. Objective: To evaluate the role of progesterone in lowering CRH level in plasma of patient with preterm labor. Methods: This study is a case control study. Forty-five pregnant women with preterm labor were included in the study and basal plasma Corticotropin releasing hormone (CRH) level was done for each patient. All patients were given oral tocolytic drug, with an initial bolus of 20 mg Nifedipine followed by 10 mg three times daily. They received betamethasone injection (12 mg) 24 hours after hospitalization. Then after stabilization of each patient with random selection, 25 patients were included in group (1) and were given progesterone injection. Twenty patients were included in group (2) or control group because no progesterone injection was given to them. After 24 hours of admission to the hospital, plasma CRH level was measured for both groups with evaluation of the outcome of each patient with preterm labor. Results: Progesterone is more effective in lowering CRH level in patients with preterm labor. In study of 45 cases of preterm labor, the mean CRH level of group (1) decreased from 33.41 ng/ml to 22.12 ng/ml, while the mean level of it in group (2) increased from 27.44 ng/ml to 28.54 ng/ml. Conclusion:Progesterone treatment is effective in lowering CRH level in patients with preterm labor. This would have a positive effect in prolonging the pregnancy period in these patients. Keywords: Preterm labor, progesterone, CRH Citation: Yaseen EM, Abd AF. Effect of progesterone in lowering maternal plasma corticotropin-releasing hormone in patients with preterm labor. Iraqi JMS. 2019; 17(1): 32-42. doi: 10.22578/IJMS.17.1.6