AbstrakKenaikan berat badan pada tikus model obesitas yang tetap diberikan pakan tinggi lemak terus berlangsung, akan tetapi jenis aktivitas fisik yang tepat mungkin dapat memperlambatnya. Penelitian ini bertujuan mengetahui perbedaan efek interval training tipe cepat, interval training tipe lambat, dan continuous training intensitas sedang terhadap berat badan, nilai indeks Lee, serta kadar adiponektin dan IL-6. Penelitian ini dilakukan di Laboratorium Farmakologi dan Terapi Fakutas Kedokteran Unpad pada bulan April-Mei 2014. Penelitian ini menggunakan posttest-only control group design pada 28 ekor tikus model obesitas (indek Lee >0,30), kadar adiponektin dan IL-6 plasma diperiksa dengan metode ELISA. Hasil penelitian menunjukkan perlakuan interval training tipe lambat lebih baik dibanding dengan interval training tipe cepat, continuous training intensitas sedang dan kontrol, yaitu kenaikan berat badan (2,34% vs 10,79% vs 4,49% vs 7,58%, p=0,000), penurunan kadar adiponektin (9,04 vs 10,27 vs 10,57 vs 7,24 ng/mL, p=0,000), glukosa (101,91±7,1 vs 113,63±6,4 vs 144,03±9,0 vs 82,24±5,9 mg/dL, p=0,000), trigliserida (28,07±3,3 vs 34,14±5,7 vs 42,00±4,9 vs 17,34±2,7 mg/dL, p=0,000), peningkatan kadar IL-6 (60,29±3,1 vs 54,55±2,1 vs 50,76±4,1 vs 56,36±2,9 pg/mL, p=0,000), dan penurunan nilai indeks Lee (7,3% vs 3,6% vs 6,4% vs 5,2%, p=0,000). Weight gain increase in obese rats that are continuously fed with fat rich chow may be slowed downs by putting them on a training regimen. This study aimed to determine the differences between the effects of fast-type interval training, slow-type interval training, and moderate-intensity continuous training on weight gain, Lee index, adiponectine, and IL-6. Using a post-test only control group, this study involved 28 obese rats (Lee index values >0.30). Adiponectin and IL-6 levels were tested using ELISA. This research was conducted in Pharmacology and

AbstrakKenaikan berat badan pada tikus model obesitas yang tetap diberikan pakan tinggi lemak terus berlangsung, akan tetapi jenis aktivitas fisik yang tepat mungkin dapat memperlambatnya. Penelitian ini bertujuan mengetahui perbedaan efek interval training tipe cepat, interval training tipe lambat, dan continuous training intensitas sedang terhadap berat badan, nilai indeks Lee, serta kadar adiponektin dan IL-6. Penelitian ini dilakukan di Laboratorium Farmakologi dan Terapi Fakutas Kedokteran Unpad pada bulan April-Mei 2014. Penelitian ini menggunakan posttest-only control group design pada 28 ekor tikus model obesitas (indek Lee >0,30), kadar adiponektin dan IL-6 plasma diperiksa dengan metode ELISA. Hasil penelitian menunjukkan perlakuan interval training tipe lambat lebih baik dibanding dengan interval training tipe cepat, continuous training intensitas sedang dan kontrol, yaitu kenaikan berat badan (2,34% vs 10,79% vs 4,49% vs 7,58%, p=0,000), penurunan kadar adiponektin (9,04 vs 10,27 vs 10,57 vs 7,24 ng/mL, p=0,000), glukosa (101,91±7,1 vs 113,63±6,4 vs 144,03±9,0 vs 82,24±5,9 mg/dL, p=0,000), trigliserida (28,07±3,3 vs 34,14±5,7 vs 42,00±4,9 vs 17,34±2,7 mg/dL, p=0,000), peningkatan kadar IL-6 (60,29±3,1 vs 54,55±2,1 vs 50,76±4,1 vs 56,36±2,9 pg/mL, p=0,000), dan penurunan nilai indeks Lee (7,3% vs 3,6% vs 6,4% vs 5,2%, p=0,000). Weight gain increase in obese rats that are continuously fed with fat rich chow may be slowed downs by putting them on a training regimen. This study aimed to determine the differences between the effects of fast-type interval training, slow-type interval training, and moderate-intensity continuous training on weight gain, Lee index, adiponectine, and IL-6. Using a post-test only control group, this study involved 28 obese rats (Lee index values >0.30). Adiponectin and IL-6 levels were tested using ELISA. This research was conducted in Pharmacology and