Malaria has been a health problem in Indonesia, including in sub-district Kaligesing, district Purworejo of Central Java Province. Malaria has also been identified as an endemic especially in the villages of Jatirejo, Kaliharjo, and Somongari. The purpose of this study was to describe the epidemiology of malaria incidence based on distribution of cases, surrounding house related cases, and the Anopheles breeding place of malaria vectors. This descriptive based research with a case study approach investigated 61 malaria cases as respondents from 2016-2018 in Jatirejo, Kaliharjo and Somongari Villages sampled using total population method. The chosen variables were behaviour and environment of the respondents in relation to the presence of Anopheles vector breeding grounds. Data were analyzed descriptively and displayed in tables and maps. The results of the analysis showed that the average age of the malaria sufferer was 34 years old, male (60.7%), and most of them (45%) were coconut farmers. The most common symptoms of malaria experienced by respondents were fever, chills, headaches, and night sweats. In addition, 24.6% did not use insecticide-treated netting while sleeping. Spatially, the highest distribution of malaria cases was identified in Jatirejo Village, as its topography is plateau with a plantation area. Meanwhile, the existence of breeding places was found surrounding respondents’ houses. To prevent from having malaria, people have been advised to take precautions by wearing long clothes when going out at night, using repellents/anti-mosquito treatments, providing larvicides at breeding sites around their house.

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