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Background:Familial Mediterranean fever (FMF) characterized by pain and inflammation with fever which requires a lifelong treatment1. All of this causes psychosocial influences and also causes kinesiophobia, which is defined as avoidance of physical activity and fear of repetition of the pain. As it may affect the levels of physical activity and functional capacity, it is important to identify factors related to kinesiophobia in patients with FMF.Objectives:The aim of this study was to investigate the existence of kinesiophobia and related factors such as depression, anxiety and physical activity in adult patients with FMF.Methods:38 subjects with FMF (15 male) from Society of Behçet & FMF Diseases included in the study. The demographic characteristics of the participants were recorded. The ‘Tampa Scale for Kinesiophobia (TSK)2’, ‘International Physical Activity Questionnaire (IPAQ)3’, ‘Hospital Anxiety and Depression Scale (HADS)4’ and ‘Fatigue Severity Scale (FSS)5’ were used to assess associated factors.Results:Demographic and disease characteristics of the participants were presented in the table 1. Only 9 subjects reported regular exercise. 86% of the subjects had a score over 37 in TSK representing high kinesiophobia6. TSK scores were positively correlated with HAD-D (r=0,530; p=0,001) and FSS (r=0,340; p=0,035). On the other hand, age, disease duration, body mass index, HAD-A and IPAQ scores were not correlated with TSK. Gender or exercise routine had no effect on TKS.Table 1Demographic and disease characteristicsMean±StdMin.Max. Age (year)37.05±8.711957Disease duration (years)13.11±11.14146BMI (kg/cm2)24.5±4.4316.6538.05IPAQ6942.5±2520.4301814580TSK44.16±5.063354HAD-A9.84±4.43220HAD-D8.82±4.70120FSS56.45±13.052370Conclusions:Kinesiophobia is very common and associated with depression and fatigue in patients with FMF. Limited number of participants reported regular exercise habit which should be added to treatment programs to increase physical activity and functional capacity in patients with FMF.References1. Makay, Emiroğlu N, Unsal E. Depression and anxiety in children and adolescents with familial Mediterranean fever. Clin Rheumatol2010Apr;29(4):375–9.2. Yılmaz OT, Yakut Y, Uygur F, Uluğ N. Turkish version of the Tampa Scale for Kinesiophobia and its test-retest reliability Fizyoterapi Rehabilitasyon2011;22(1):44–49.3. Sağlam M, Arıkan H, Savcı S, Inal-Ince D, Boşnak-Güçlü M, Karabulut E, et al. International physical activity questionnaire: reliability and validity of the Turkish version. Perceptual and motor skills2010;111(1):278–84.4. Aydemir O, Güvenir T, Küey L, Kültür S. Reliability and Validity of the Turkish version of Hospital Anxiety and Depression Scale. Turkish journal of psychiatry1997;8(4):280–287.5. Armutlu K, Korkmaz NC, Keser I, Sumbuloglu V, Akbiyik DI, Guney Z, Karabudak R. The validity and reliability of the Fatigue Severity Scale in Turkish multiple sclerosis patients. Int J Rehabil Res. 2007Mar;30(1):81–5.6. Vlaeyen J, Kole-Snijders AMJ, Rotteveel AM, Ruesnik R, Heuts PHTG. The role...