Effective treatment is being sought for the discovery of antifungal compounds.One of Plants that are suspected as a potential antifungal is Gambir (Uncaria gambierRoxb.). Gambir contains high antioxidants. Gambier containing catechin, katekutannat, quercetin, gallic acid, and catechol elagat acid, has been studied to determine its antifungal activity. This study was done by using experimental in vitro tube dilution method. The general objective of this study was to investigate the inhibition of ethanolic extract and water extract of gambier towards the growth of Candida albicans. Specific objectives were to determine Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC)of ethanolic extract and water extract of gambier towards the growth of Candida albicans. The concentration used were 50% , 60% , 70% , 80% , 90% and 100% . The results showed thatMICof the ethanolic extract of gambier could not be determined, while the MBCwas 100%. One Way ANOVA statistical analysis results showed p= 0.004 ( p< 0.05 ), indicating significant differences in changes of the concentration of ethanol extract gambier to the number of colonies ofCandida albicans. Correlation test showed a close relationship between the concentration of gambier extract and the number of colonies ( r = -9.900 : p < 0.05 ). Regression test yielda linear regression equation Y = 5,034-0,048x with R Square coefficient ( r2 ) of 0.802. Based on the research results it can be concluded that the ethanolic extract of gambier has antifungal effect against Candida albicans.

Aloe vera was a traditional medicinal plant that can react as an adjuvant to increase the immune response to antigens because of that Aloe vera was called an immunomodulator. Salmonella typhi bacteria can be destroyed and eliminated by improving macrophage function. This can be done using immunostimulants that have a function as immunomodulators. One plant that acts as an immunostimulant is Aloe vera. The Widal test is one method that utilizes immunology to determine levels of antibodies in the serum, to help diagnose typhoid fever. Based on the description, a study was conducted to see the effect of Aloe vera gel on widal titer in rats that were ingested by Salmonella typhi. This study used white male rats (Rattusnorvegicus L.) strain Wistar, body weight 200 grams consisting of 4 groups with 2 treatments 7 times repetition, namely P1 (Aloe vera gel 1.8 ml/200g/Bw), P2 (Aloe vera gel 3.6 ml/200g/Bw), control (+) ingested Salmonella typhi bacteria and not using Aloe vera gel, (-) using distilled water. The collected data includes objectively tested data, namely Widal titers. The Mann Whitney test results showed that Aloe vera gel affected the decrease of tidal titer (antibodies) in white rats which had been indicated by Salmonella typhimurium bacteria (P <0.05).