Abstract:In the trials, Cassava mill Effluent was used for fluted pumpkin (Telfairia occidentalis) cultivation in order to verify the influence of the effluent on the growth and some soil chemical properties. In this regard, a completely randomized and randomized complete block designs were used in the greenhouse and field trials respectively with 6 treatments replicated 3 times. In the greenhouse, the following rates of 0, 100, 200, 300, 400 and 500 ml per 5 kg topsoil were used while in the field trial, 0, 40000, 80000, 120000, 160000 and 200000 litres/ha were utilized. The rates used in the field were equivalent to those of greenhouse. In both trials, the cassava mill effluent was applied 2 weeks prior to transplanting the seedlings. Results indicated that the cassava mill effluent significantly (P < 0.05) increased soil pH, organic carbon, N, P, K, Ca, Mg, Na, Fe, Cu and Zn whereas the exchangeable acidity decreased significantly (P < 0.05) with corresponding increase in cassava mill effluent treatments. Except N and Na, which declined with corresponding increase in the cassava mill effluent treatments, an improved P, K, Mg, Ca, Fe, Cu and Zn components was achieved in cassava mill effluent polluted plants compared to control. The plant height, significantly (P < 0.05) decreased with increased cassava mill effluent treatment in the greenhouse trial while in the field trial, 120000 litres/ha was significantly (P < 0.05) higher than other treatments. In the greenhouse trial, significantly (P < 0.05) higher number of leaves was attained in 100 ml treatment compared to other treatments whereas in the field trial, the 120000 and 200000 litres/ha were significantly (P < 0.05) higher compared to other treatments