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PurposeTo report toxic anterior segment syndrome (TASS) after cataract surgery possibly associated with intracameral use of cefuroxime.MethodsWe conducted a retrospective chart review and analysis on the pre- and postoperative conditions of the subjects who had developed TASS.ResultsThe patient group consisted of 17 patients. Tyndallization and fibrin fibers were positive in all eyes. In four eyes, hypopyon formation developed. These reactions diminished on the third day and fully resolved 1 week after the operations with the use of intensive topical steroid and mydriatic therapy. To determine the etiology of TASS, infusion fluid, viscoelastics, and intracameral antibiotic agent were changed respectively. After changing intracameral antibiotic agent from cefuroxime axetile to moxifloxacin no new cases of TASS were diagnosed.ConclusionAll agents injected into the anterior chamber can cause TASS. Ophthalmologists and operating room staff need to pay careful attention to all drugs and irrigating solutions.

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