In this study, we aimed to examine the effect of neutrophil-lymphocyte ratio (NLR) on mortality and morbidity in elderly patients over the age of 65 who presented to our clinic and were operated on due to hip fracture. Methods The study included patients over the age of 65 who were operated on in our hospital between January 2014 and December 2018 due to hip fracture. Those with multiple fractures and those who were operated on due to cancer-related fracture were excluded. Patients' age, gender, American Society of Anesthesiologists (ASA) score, preoperative waiting time, type of anesthesia, operation duration, amount of erythrocyte suspension used, and duration of intensive care unit (ICU) stay were recorded. The effect of increased preoperative and postoperative 5th day neutrophil-lymphocyte ratios (NLR 1 and NLR 5, respectively) on mortality and morbidity was investigated. Results We examined 132 patients operated on due to hip fracture. NLR 5 was higher among patients who were admitted to the ICU (p = 0.007) and among those who died (p = 0.007). Additionally, the rate of increase of NLR 5 was higher among patients who were admitted to the ICU (p = 0.044) and among those died (p = 0.009). Conclusion The rate of increase of NLR in the postoperative period can be used as a criterion for predicting mortality in patients who are operated on due to hip fracture.

to-lymphocyte and fibrinogen-to-albumin ratios may be indicators of worse outcomes in ICU patients with COVID-19.

Introduction: Evaluation of the prognosis in the early period of intensive care patients and arranging the treatment accordingly is of vital importance. In the present study, we investigated whether serum thiol/disulphide concentration can be used in the follow-up of prognosis in the early period in patients with COVID-19 under intensive care.Methods: The study included 25 patients [their ages were between 19 and 92; 10 (40%) were male and 15 (60%) were female] who were diagnosed with COVID-19 and treated in the intensive care unit (ICU). The patients were followed for four weeks. On the first, third, and fifth days of intensive care treatment, venous blood samples were taken from the patients to analyze the thiol/disulphide parameters, and coma scores were calculated. Statistical analyses were conducted to evaluate the relationship between thiol/disulphide levels and the prognosis of COVID-19 patients.Results: At the end of the four-week follow-up of the patients included in the study, 9 were discharged and 16 died. In patients who died, the relationship between thiol/disulphide homeostasis parameters and coma scores was not statistically significant. Meanwhile, in discharged patients, the relationship between disulphide concentration, total thiol, and coma scores was statistically significant. Conclusion:The relationship between thiol/disulphide homeostasis and coma scores in COVID-19 patients treated in the intensive care unit may help to evaluate the prognosis of the disease in the early period, thus the effectiveness of medical intervention.

Objective: Current guidelines recommend a period of moderate targeted temperature management (TTM) for post cardiac arrest patients (PCA) to improve clinical outcomes. A prognostic value related to survival in patients receiving TTM was not fully established. In this study, we aimed to investigate the relationship between mean platelet volume (MPV) and mortality in PCA patients undergoing TTM. Method: This was a single-center, retrospective cohort study included 15 patients who suffered from cardiac arrest and underwent TTM within 6 hours of cardiac arrest. Hypothermia was maintained for 48h at a target temperature of 34°C. We examined all data about characteristic features of PCA patients s as well as MPV within the first 96 hours from admission. Results: Of the 15 patients, 11 (73.3%) died during hospital stay. At time points of T0, T1, T2, T3, T4 24 hour ie. a total of 5 times hemogram values were determined. The change of all values except red cell distribution width (RDW) values over time was found to be significant (P<0.05).When surviving patients were evaluated relative to deceased patients only MPV T1, T2 and T4 values showed statistically significant changes. As MPV cut-off value of T4 7.63 was determined (AUC=1.00, 95% CI:1.00-1.00, p=0.004 with a sensitivity and specificity of 100% and 100%, respectively). Conclusion:The second day values of MPV after TTM is an independent predictor of survival in PCA patients treated with TTM. Changes in MPV can be used to predict survival in these patients.

Amaç: Akrep sokmalarına bağlı olarak oluşan zehirlenmeler ve getirdiği sonuçlar dünyada güncelliğini koruyan sağlık problemlerindendir. Akrep sokmaları bölgemizde, özellikle ilimiz ve çevresinde yaygın olarak görülmektedir. Dünyada tanımlanmış olan 1500’den fazla akrep türünün sadece birkaç tanesi çok zehirlidir ve Türkiye’de 15 tür akrep bulunduğu tahmin edilmektedir. Bu çalışmada akrep sokması nedeniyle hastanemiz yoğun bakım ünitesi (YBÜ)’de takip ettiğimiz hastaların demografik verileri, epidemiyolojik, klinik özellikleri ve sonuçları değerlendirildi. Materyal ve metod: Etik kurul onayı (HRÜ/23.03.11) alındıktan sonra Ocak 2013- Ocak 2023 tarihleri arasında Harran Üniversitesi Hastanesinde akrep sokması ön tanısıyla takip ve tedavi edilen hastaların arşiv verileri değerlendirildi. Sistemik belirti gösteren ve özellik arz eden erişkin hastalarla ilgili genel YBÜ’ deki tedavi yaklaşımları, epidemiyolojik ve klinik sonuçlar değerlendirildi. Bulgular: Çalışmamıza dahil edilen, akrep sokması tanısıyla hastanemizde tedavi gören 1493 hastanın 910’u &gt;17 yaş hastalardı. Bunların da 74’ü üçüncü seviye YBÜ’ de tedavi gören hastalardı. Erişkin YBÜ’ de tedavi gören hastaların %25,7’si (n= 19) erkek, %74,3’ü (n=55) kadındı. Hastaların yaşı 18 ile 88 arasında değişmekteydi. Kadın hastaların %43,6’sı (n=24) gebeydi. En sık görülen semptom, lokal ağrı (%98,6, n=73) idi. Çoğunlukla alt (%52,7) ve üst (%44,6) ekstremitelerin etkilendiği görüldü. Hastaların %70,3’ü (n=52) profilaktik amaçlı tetanoz antiserum, %56,8’si (n=42) anti-venom tedavisi aldı. Gebe hastalara ağrı kesici olarak intravenöz parasetamol uygulandı. Gebe hastalara hastaneye yatışta ve taburculuk öncesi obstetrik USG yapılmış olup herhangi bir komplikasyona rastlanılmadan şifayla taburcu edildi. Hastaların tamamının şifayla taburcu edildiği görüldü. Sonuç: Akrep sokmasına bağlı sistemik belirtileri olan ve gebelik gibi özellik arz eden durumu olan hastaların, YBÜ’de yakın takip ve tedavisi, ölüm oranlarının azaltılmasına katkı sağlayabilir. Akrep sokmalarına kırsal bölgelerde özellikle kadın hastalarda ve gebelerde sıklıkla rastlanılmaktadır. Bunun, bölgemizdeki tarım alanlarında çoğunlukla 15-49 yaş kadınların çalışmasına bağlı olabileceğini düşünmekteyiz. Bu sonuçların, yapılacak daha geniş kapsamlı halk sağlığı çalışmalarıyla desteklenmesi gerektiğini düşünmekteyiz.