Background: COVID-19 has impacted healthcare delivery across every setting and patient population since it began ravaging our communities in the early part of 2020. The impact of the pandemic has propelled changes in healthcare delivery incorporating new technologies and resulting at times to interruptions in care and impacting access to treatment. The aim of this study is to understand the various ways in which the COVID-19 pandemic has affected mental health overall and particularly in those with psychotic disorders who are particularly vulnerable to disruptions in their access to care and to their usual routines. There is evidence that mental health is negatively affected during epidemics and public health crises. The unique nature and scale of the COVID-19 pandemic in modern times presents an opportunity to learn more about the challenges faced by our patients and improvements that can be made in the delivery of mental health care.

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Myocardial infarction (MI) can have significant physical and mental consequences. Depression is a prevalent psychiatric condition after MI which can reduce the quality of life and increase the mortality rates of patients. However, the connection between MI and depression has remained under-appreciated. This review examines the potential connection between depression and MI by overviewing the possible pathophysiologic mechanisms including dysregulation of the hypothalamic-pituitary-adrenal axis and autonomic nervous system, coagulation system dysfunction, inflammation, environmental factors, as well as, genetic factors. Furthermore, depression can be an adverse event of medications used for MI treatment including beta-blockers, statins, or anti-platelet agents. The need for early detection and management of depression in patients with MI is, therefore, crucial for improving their overall prognosis. Adherence to treatments and regular follow-up visits can ensure the best response to treatment.